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Downregulated pathways generally involved the cytoskeleton and cytokine secretion/response and included: Wound Healing Signaling, Acute Phase Response Signaling (rapid reprogramming of gene expression and metabolism in response to inflammatory cytokine signaling), Pulmonary Fibrosis Idiopathic Signaling Pathway, Regulation of EMT by Growth Factors Pathway, Actin Cytoskeleton Signaling, and IL-6 Signaling (Fig